David Sinclair of Harvard University has been working toward a molecular fountain of youth. Finding previous success in mice, early human trials have begun in small studies around the globe. Preliminary results of these studies indicate that the treatments are safe and do not induce major adverse side effects, but it is still far too early to tell if the treatments will actually be effective at reversing aging in humans.
A normal part of human aging involves senescence, which is a general wearing out of the body over time. Muscles begin to lose tone and become inflamed over time, and they also can develop insulin resistance. Without being able to use insulin, the cells aren’t able to uptake the glucose needed for activity. These problems contribute to why many elderly people have trouble getting around and athletes aren’t able to sustain certain levels of activity as they age.
Last December, Sinclair’s group published a paper in Cell revealing that they had been able to drastically reduce the functional “age” of muscle tissue. Treating the mice with the metabolic co-enzyme NAD+ effectively reversed the aging process within the skeletal muscle by increasing muscle tone and producing effects similar to eating a healthy diet and exercising.
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STORY: http://www.huffingtonpost.com/2014/10/27/justice-alito-brunch_n_6056428.html?ir=Politics